Narcolepsy Risk DNA Test

Do you struggle to stay awake throughout the day? You may have narcolepsy, a sleeping disorder caused by disrupting the balance between sleep-awake cycles. Take this DNA test to find out whether your involuntary daytime naps may be due to narcolepsy.

  Detects the HLA-DQB1*06:02 variant

 Buccal swab sample collection

$195.00

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What's included?

Detailed Description

What is Narcolepsy?
Narcolepsy is a neurological disorder characterized by extreme daytime sleepiness and uncontrollable episodes of falling asleep during the day. This excessive daytime sleepiness should not be mistaken for the afternoon slump, since neurological defects are responsible for narcolepsy, rather than just sleep deprivation or lack of caffeine!

How Common is Narcolepsy?
Between 1 in 2000 and 1 in 5000 people are affected by narcolepsy. However, only about 25% of the cases are correctly diagnosed, and often narcoleptics are mistakenly diagnosed with psychiatric or emotional problems. Family members of an affected individual also have a 20X – 40X increased risk of developing narcolepsy.

This genetic analysis detects the HLA-DQB1*06:02 allele associated with narcolepsy. It is a useful tool, in conjunction with other clinical symptoms, for an accurate narcolepsy diagnosis.

The Genetics

Approximately 90-99% of people with narcolepsy carry a variant of the HLA-DQB1 gene known as the HLA-DQB1*06:02 allele.

  •  Two copies of HLA-DQ1b*06:02 = 7X – 25X increased risk of narcolepsy (or potentially up to 250X increased risk!)
  •  One copy of HLA-DQB1*06:02 + an alternative HLA-DQB1 allele = 3X increased risk (depending on the risk or protective affect of the alternative allele)
  •  Absence of HLA-DQB1*06:02 = Low risk of narcolepsy

However, 15 – 25% of the unaffected people, also carry the HLA-DQB1*06:02 variant, suggesting genetics is not the only factor that contributes to narcolepsy. Multiple other HLA-DQB1 variants also exist, and many of these provide some protection from narcolepsy, complicating the risk analyses.

Symptoms of Narcolepsy

How many diabetes risk factors do you have?

  • Excessive daytime sleepiness (100% of affected individuals)
  • Cataplexy – a sudden loss of voluntary muscle tone (70% of affected individuals)
  • Sleep paralysis and/or vivid hallucinations (10 to 20% of affected individuals)
  • Microsleep (sleep episodes that only last a few seconds)
  • Nighttime wakefulness
  • Atonia (loss of muscle strength)
  • Involuntary leg muscle contractions
  • Rapid entry into REM sleep

CLIA Certified

All Genofit tests are guaranteed to be processed by a CLIA certified laboratory–the same type of certification as hospital laboratories.

Physician Reviewed

Genofit tests are reviewed and approved by a third-party independent physician licensed to practice within your state.

HIPAA Compliant

Genofit takes measures to guarantee your privacy. Your personal data is securely stored and will not shared with any third-party without your permission.

Get Started in 3 Easy Steps​

Get Started in 3 Easy Steps

1. Activate Kit

Activate your kit online at genofit.com by entering the unique activation code found inside your kit.

2. Collect & Mail Sample

Simply collect your sample at home, then mail your sample directly to the lab with free return shipping.

3. View Results

Receive your results within 5-7 business days after the lab receives your kit.

FAQ's

Here are the answers to the most frequently asked questions about this test.

Yes, your results are 100% confidential. No one will be able to access your account or your results unless you give them your confidential account login. You can change the password to your account at any time. Please remember to safeguard your login information and not share it with anyone.
Testing begins immediately the day that your samples arrive at the laboratory. In some special situations, additional testing may be required, which could increase the turnaround time by a few extra days. You can check the status of your test online 24/7 using your secure account login. Your test report is released immediately once testing is complete.
Drinking or eating will not change the results in any way. The reason that you are not supposed to drink or have anything in the mouth for an extended period prior to collection is to ensure that we have enough buccal cells to complete the test. If there are not enough cells to complete the test, then the results will not be released and a recollection will be required.
No. You can send the kits back to the laboratory using any shipping method of your choosing. Please be advised that if you do not use the included prepaid return mailer to ship your samples, it is your responsibility to ensure that your samples arrive at the laboratory. We will not be able to provide assistance for shipments that do not use our prepaid return mailer.

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