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DNA Narcolepsy Test

DNA Narcolepsy Test

$129.00 CAD
$129.00 CAD
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Understand Your Genetic Risk for Narcolepsy

Discover if you carry the genetic variant most strongly associated with narcolepsy risk. With a simple, painless mouth swab, our DNA Narcolepsy Test analyzes the HLA-DQB1*06:02 variant—found in over 95% of people with narcolepsy with cataplexy and significantly elevated in those with narcolepsy without cataplexy.

This test is particularly valuable if you experience excessive daytime sleepiness, sudden sleep attacks, muscle weakness triggered by emotions, or have been told you have unusual REM sleep patterns.

 
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Turnaround Time
4-6 weeks
Sample Type
Mouth Swabs
Genes Tested
HLA-DQB1
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Benefits You’ll Love

Easy, Painless Mouth Swabs

Free delivery on all orders

Private & Confidential

Actionable Genetic Insights

Get Started in 3 Easy Steps

  • 1. Purchase Kit

    Order a Genofit test online and we'll ship your test kit directly to your doorstep.

  • 2. Collect & Mail

    Simply collect your sample at home, then mail your sample directly to the lab with free return shipping.

  • 3. Receive Results

    Download your report from your secure online account shortly after the lab receives your sample.

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Why Genetics Matter for Narcolepsy

Narcolepsy, particularly Type 1, has one of the strongest known genetic associations of any autoimmune disorder. The specific gene variant analyzed in this test, HLA-DQB1*06:02, is found in over 90% of individuals who have narcolepsy with cataplexy (sudden muscle weakness).

Narcolepsy is a chronic neurological disorder that affects the brain's ability to regulate sleep-wake cycles, causing excessive daytime sleepiness, sudden sleep attacks, and sometimes cataplexy (sudden muscle weakness). While narcolepsy affects about 1 in 2,000 people, it's often misdiagnosed or undiagnosed for years.

What We Test

This test analyzes your DNA for the presence or absence of the HLA-DQB1*06:02 genetic variant. This specific variant within the human leukocyte antigen (HLA) system is the most significant genetic risk factor for narcolepsy. The HLA system normally helps your immune system distinguish between your own cells and foreign substances.

The presence of HLA-DQB1*06:02 suggests an increased susceptibility to the autoimmune process that researchers believe destroys hypocretin-producing neurons in the brain—the cells responsible for regulating wakefulness and REM sleep. When these neurons are damaged or destroyed, it leads to the characteristic symptoms of narcolepsy.

What Your Results Mean

It is important to understand what this test can and cannot do. A positive result for the HLA-DQB1*06:02 variant does not mean you have or will develop narcolepsy, as this variant is also present in a significant portion of the general population.

However, a negative result can be very informative, as it makes a diagnosis of narcolepsy type 1 highly unlikely. For individuals experiencing unexplained sleepiness, this test can be an essential step in the diagnostic process, helping doctors to rule out or investigate narcolepsy as a potential cause. It provides a critical piece of the puzzle when evaluated alongside your symptoms and clinical history.

Why Genofit?

  • Trusted for Accuracy

    Our laboratory meets the highest standards with globally recognized accreditations to deliver reliable results every time.

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  • Your Privacy Matters

    We prioritize your privacy with a password-protected online portal, ensuring that your results are accessible only to you.

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  • Support From Experts

    Our dedicated customer care team is ready to guide you through every step, answer your questions, and provide the assistance you need.

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