Comprehensive Analysis of 4 Critical Thrombotic Mutations

The DNA Thrombotic Risk Test analyzes specific mutations in three genes that are known to influence the body's clotting system. Understanding these genetic factors provides a clearer picture of your personal risk profile.

F5 Gene - The Factor V Leiden Mutation

This is the most common inherited factor for blood clotting disorders, present in 3-8% of people of European descent. The mutation makes a key clotting protein (Factor V) resistant to being "turned off," which can heighten clot risk, especially during pregnancy, surgery, or while using hormonal medications. Inheriting one copy can increase risk 3-8 times, while two copies can increase it 50-100 times over the baseline.

F2 Gene - The Prothrombin Mutation

This mutation causes the body to produce too much prothrombin, a primary protein needed for blood to clot. The resulting surplus can increase clot risk 2-4 times and is a common factor in unexplained clots, particularly in younger adults. The risk is significantly higher when combined with other factors like hormonal birth control.

MTHFR Gene - Two Common Mutations

These variants (677C>T and 1298A>C) affect how the body processes folate, which can lead to higher levels of an amino acid called homocysteine. Elevated homocysteine can damage blood vessel linings, potentially increasing clot risk. The 677C>T variant has a more significant effect, while the 1298A>C variant has a milder impact but can contribute to overall risk.

It's important to note that having mutations in more than one of these genes can multiply the overall risk. For example, carrying both a Factor V Leiden and a prothrombin mutation can increase the risk of a blood clot by 20 times or more.