The Science of Your Bone Health

Your likelihood of developing osteoporosis and experiencing fractures is significantly influenced by variations in five key genes that control how your body builds, maintains, and repairs bone tissue. These genetic variations affect people in different ways:

CYP2R1 Gene Variants

Your body's ability to activate vitamin D varies based on this gene. Some people efficiently convert vitamin D to its active form, while others may need more support through supplements or sun exposure to maintain optimal bone health.

GC Gene Variants

Your body's vitamin D transport system works differently depending on these genetic variations. Some people effectively deliver vitamin D throughout their body, while others may need higher levels to achieve the same bone-building benefits.

WNT16 Gene Variants

Your bone formation signaling varies with this gene. Some people have enhanced bone-building communication between cells, while others may benefit from targeted exercise and nutrition to support optimal bone density.

GDF5 Gene Variants

Your bone and joint development patterns are influenced by this gene. Some people naturally build stronger bones that respond well to physical activity, while others may need more focused bone-building strategies.

COL1A1 Gene Variants

Your body's collagen production—the foundation of strong bones—varies based on this gene. Some people efficiently produce high-quality bone matrix, while others may benefit from specific nutrients that support collagen synthesis.